RH Logo
Hubs
About
Live
Leaderboard

My Hubs
All

Trending Papers in Cell Biology

Trending
Today
Trending
Today

Sign in to discover all of the research papers you care about, live as they're published.

3
Date Added: May 10, 2021
Authors: Clare Y. Slaney, Pin Wang, Phillip K. Darcy, Michael H. Kershaw
Date Added: May 10, 2021
Authors: Clare Y. Slaney, Pin Wang, Phillip K. Darcy, Michael H. Kershaw
The redirection of T cells against tumors holds much promise for the treatment of cancer. Two main approaches for T-cell redirection involve their genetic modification with chimeric antigen receptors (CAR), or the use of recombinant proteins designated bispecific T-cell engagers (BiTE). These approaches have demonstrated dramatic effects in patients with hematologic cancers, although limited effect against solid cancers. Here, we review and compare the successes and challenges of these two types of immunotherapies, with special focus on their mechanisms, and discuss strategies to improve their efficacy against cancer. Significance: CAR and BiTE cancer therapies have generated much excitement, but although the therapies are potentially competitive, information directly comparing the two is difficult to obtain. Here, we present the fundamentals of each approach and compare the range and level of functions they can elicit from T cells, and their efficacy against cancers. Cancer Discov; 8(8); 924–34. ©2018 AACR.
2
Date Added: Apr 30, 2021
Authors: Monique D. Appelman, Jochen M. Wettengel, Ulrike Protzer, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf
Date Added: Apr 30, 2021
Authors: Monique D. Appelman, Jochen M. Wettengel, Ulrike Protzer, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf
Load More Papers