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Trending Papers in clinical trials

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258
From Paper: ECTOPIC ACTH PRODUCTION CAUSED BY METASTATIC PAROTID GLAND ACINIC CELL CARCINOMA
From Paper: ECTOPIC ACTH PRODUCTION CAUSED BY METASTATIC PAROTID GLAND ACINIC CELL CARCINOMA
  • Familial paraganglioma syndrome type 4 is associated with mutations in the succinate dehydrogenase complex subunit B (SDHB) gene.
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Chukwuma Chidera
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Chukwuma Chidera
228
From Paper: Skeletal Complications with GNAS mutation: An Unusual Case with Osteoma Cutis, Gout, and Synovial Chondromatosis in a Patient with Pseudopseudohypoparathyroidism
From Paper: Skeletal Complications with GNAS mutation: An Unusual Case with Osteoma Cutis, Gout, and Synovial Chondromatosis in a Patient with Pseudopseudohypoparathyroidism
  • Familial paraganglioma syndrome type 4 is associated with mutations in the succinate dehydrogenase complex subunit B (SDHB) gene.
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Chukwuma Chidera
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Chukwuma Chidera
2
Authors: Kommoss, Stefan, et al
Published: Jul 2017
Authors: Kommoss, Stefan, et al
Published: Jul 2017
Purpose: Recent progress in understanding the molecular biology of epithelial ovarian cancer has not yet translated into individualized treatment for these women or improvements in their disease outcome. Gene expression has been utilized to identify distinct molecular subtypes, but there have been no reports investigating whether or not molecular subtyping is predictive of response to bevacizumab in ovarian cancer.Experimental Design: DASL gene expression arrays were performed on FFPE tissue from patients enrolled on the ICON7 trial. Patients were stratified into four TCGA molecular subtypes. Associations between molecular subtype and the efficacy of randomly assigned therapy with bevacizumab were assessed.Results: Molecular subtypes were assigned as follows: 122 immunoreactive (34%), 96 proliferative (27%), 73 differentiated (20%), and 68 mesenchymal (19%). In univariate analysis patients with tumors of proliferative subtype obtained the greatest benefit from bevacizumab with a median PFS improvement of 10.1 months [HR, 0.55 (95% CI, 0.34–0.90), P = 0.016]. For the mesenchymal subtype, bevacizumab conferred a nonsignificant improvement in PFS of 8.2 months [HR 0.78 (95% CI, 0.44–1.40), P = 0.41]. Bevacizumab conferred modest improvements in PFS for patients with immunoreactive subtype (3.8 months; P = 0.08) or differentiated subtype (3.7 months; P = 0.61). Multivariate analysis demonstrated significant PFS improvement in proliferative subtype patients only [HR, 0.45 (95% CI, 0.27–0.74), P = 0.0015].Conclusions: Ovarian carcinoma molecular subtypes with the poorest survival (proliferative and mesenchymal) derive a comparably greater benefit from treatment that includes bevacizumab. Validation of our findings in an independent cohort could enable the use of bevacizumab for those patients most likely to benefit, thereby reducing side effects and healthcare cost. Clin Cancer Res; 23(14); 3794–801. ©2017 AACR.
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Chen Wang
114
Authors: Carpenter, Joseph K., et al
Published: Jan 2018
Authors: Carpenter, Joseph K., et al
Published: Jan 2018
The purpose of this study was to examine the efficacy of cognitive behavioral therapy (CBT) for anxiety-related disorders based on randomized placebo-controlled trials. We included 41 studies that randomly assigned patients (N = 2,843) with acute stress disorder, generalized anxiety disorder (GAD), obsessive compulsive disorder (OCD), panic disorder (PD), posttraumatic stress disorder (PTSD), or social anxiety disorder (SAD) to CBT or a psychological or pill placebo condition. Findings demonstrated moderate placebo-controlled effects of CBT on target disorder symptoms (Hedges’ g = 0.56), and small to moderate effects on other anxiety symptoms (Hedges’ g = 0.38), depression (Hedges’ g = 0.31), and quality of life (Hedges’ g = 0.30). Response rates in CBT compared to placebo were associated with an odds ratio of 2.97. Effects on the target disorder were significantly stronger for completer samples than intent-to-treat samples, and for individuals compared to group CBT in SAD and PTSD studies. Large effect sizes were found for OCD, GAD, and acute stress disorder, and small to moderate effect sizes were found for PTSD, SAD, and PD. In PTSD studies, dropout rates were greater in CBT (29.0%) compared to placebo (17.2%), but no difference in dropout was found across other disorders. Interventions primarily using exposure strategies had larger effect sizes than those using cognitive or cognitive and behavioral techniques, though this difference did not reach significance. Findings demonstrate that CBT is a moderately efficacious treatment for anxiety disorders when compared to placebo. More effective treatments are especially needed for PTSD, SAD, and PD.
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Anton Lebed
7
Authors: Stephen J. Seligman
Published: Jul 2020
Authors: Stephen J. Seligman
Published: Jul 2020
  • YFV is the eponymous virus for the genus Flavivirus. Originally isolated in 1927 from a patient in what is now Ghana, the nucleotide sequence of the vaccine virus derived from YFV was reported in 1985. YFV persists as the cause jungle yellow fever transmitted by various mosquito species
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Titus Osikhiana Ogahbrai
5
Published: Oct 2020
Published: Oct 2020
  • Conclusions Data from four nationally representative birth cohorts suggests that alcohol use during the pandemic increased in up to thirty percent of individuals. Hazardous drinking was observed in up to ten percent of respondents. Stress and inhibitory control were related to this but effects were age dependent. Governments should carefully consider the impact of personality and stress that may affect alcohol consumption in at-risk individuals.
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Anna Takadii
4
Authors: Maclachlan, Kylee, et al
Published: Nov 2020
Authors: Maclachlan, Kylee, et al
Published: Nov 2020
  • In the CoMMpass dataset it is shown that CN signatures independently associate with shorter progression free (PFS) and overall survival (OS). Finally, to accelerate the clinical translation of testing for chromothripsis where WGS data is not available, the analysis is extended to whole exome sequencing (WES), where it confirm the ability of CN signatures to predict the presence of chromothripsis and show it is associated with adverse clinical outcomes.
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Titus Osikhiana Ogahbrai
25
From Paper: Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial
Authors: Yang, Tong, et al
Published: Nov 2020
From Paper: Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial
Authors: Yang, Tong, et al
Published: Nov 2020
  • Vitamin D supplementation for 12 months appears to improve cognitive function through reducing oxidative stress regulated by increased TL in order adults with MCI. Vitamin D may be a promising public health strategy to prevent cognitive decline.
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T A
4
Medical research has evolved, from individual expert described opinions and techniques, toscientifically designed methodology-based studies. Evidence-based medicine (EBM) wasestablished to re-evaluate medical facts and remove various myths in clinical practice. Researchmethodology is now protocol based with predefined steps. Studies were classified based on themethod of collection and evaluation of data. Clinical study methodology now needs to complyto strict ethical, moral, truth, and transparency standards, ensuring that no conflict of interest isinvolved. A medical research pyramid has been designed to grade the quality of evidence andhelp physicians determine the value of the research. Randomised controlled trials (RCTs) havebecome gold standards for quality research. EBM now scales systemic reviews and meta-analysesat a level higher than RCTs to overcome deficiencies in the randomised trials due to errors inmethodology and analyses
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itatchi uchiwa
9
  • Hence, there is evidence that perceived sports competence affects hierarchically superior selfconcept dimensions, such as global physical self-concept and global self-esteem, especially when considered to be of great importance.
  • The central findings of this study revealed that individual differences in early adolescents’ importance of sports competence explain variations in the relationship between perceived sports competence and global self-esteem, yet normative gender-specific differences do not
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Terry James
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