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Trending Papers in covid-19

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Today
18
Pollen Explains Flu-Like and COVID-19 Seasonality
  • The results found a highly significant inverse association between pollen and changes in flu-like incidence corrected for incubation period.
  • Within this study, the authors combined changes in flu-like incidence per 100K/Dutch citizens with weekly pollen counts and meteorological data for the same period
Submitted by Patrick Joyce
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12
The solidarity trial - exploring repurposed antiviral drugs for efficacy in treating COVID-19
From Paper: Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results
Published: Oct 2020
  • The main outcomes of mortality, initiation of ventilation and hospitalization duration were not clearly reduced by any study drug
  • Hydroxychloroquine and Lopinavir were discontinued for futility on June 18 and July 4, 2020, respectively; Interferon is ceasing on October 16
Submitted by Patrick Joyce
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3
Testing the association between blood type and COVID-19 infection, intubation, and death
Published: Sep 2020
  • The authors estimated Rh-negative blood type to have a protective effect on infection, intubation, and death
  • The results showed the risk of infection was slightly increased for those with type-O blood, and the risk of death was increased for those with type AB blood
Submitted by Patrick Joyce
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6
SARS-CoV-2 can survive for over 9 hours on human skin
From Paper: Survival of SARS-CoV-2 and influenza virus on the human skin: Importance of hand hygiene in COVID-19
  • The survival time was significantly longer for SARS-CoV-2 than for IAV [9.04 h (95% confidence interval: 7.96–10.2 h) vs. 1.82 h (1.65–2.00 h)]
  • The results show that SARS-CoV-2 may have a higher risk of contact transmission than IAV because it is much more stable on human skin. These findings support the hypothesis that proper hand hygiene is important for the prevention of the spread of SARS-CoV-2
Submitted by Patrick Joyce
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6
Mild, moderate, and severe cases of COVID-19 each have unique immune response signatures
From Paper: Different innate and adaptive immune response to SARS-CoV-2 infection of asymptomatic, mild and severe cases
Authors:
Carsetti, Rita, et al
Published: Sep 2020
  • The importance of innate NK cells and the short-lived antibody response of asymptomatic individuals and patients with mild disease suggest that only severe COVID-19 may result in protective memory established by the adaptive immune response
  • The results show that high frequency of natural killer cells and early and transient increase of specific IgA, IgM and, to a lower extent, IgG are associated to asymptomatic SARS-CoV-2 infection
Submitted by Patrick Joyce
16
Dengue fever may provide some immunity to COVID-19
From Paper: How super-spreader cities, highways, hospital bed availability, and dengue fever influenced the COVID-19 epidemic in Brazil
Published: Sep 2020
  • The authors identified negative correlations between COVID-19's incidence, infection growth rate, and mortality to the percentage of people with antibody (IgM) levels for dengue fever in each of the country's states
  • The inverse correlation between COVID-19 and dengue fever was further observed in a sample of countries around Asia and Latin America, as well as in islands in the Pacific and Indian Oceans
Submitted by Will McBurnie
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5
People with low vitamin D levels are more likely to test positive for SARS-COV-2 infection
From Paper: SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels
Published: Sep 2020
  • These results provide further rationale to explore the role of vitamin D supplementation in reducing the risk for SARS-CoV-2 infection and COVID-19 disease
  • The SARS-CoV-2 positivity rate was higher in the 39,190 patients with “deficient” 25(OH)D values (<20 ng/mL) (12.5%, 95% C.I. 12.2–12.8%) than in the 27,870 patients with “adequate” values (30–34 ng/mL) (8.1%, 95% C.I. 7.8–8.4%) and the 12,321 patients with values ≥55 ng/mL (5.9%, 95% C.I. 5.5–6.4%)
Submitted by Patrick Joyce
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5
Covid-19: Do many people have pre-existing immunity?
Published: Sep 2020
  • The placebo arm of a covid-19 vaccine trial could provide a straightforward way to carry out such a study, by comparing the clinical outcomes of people with versus those without pre-existing T cell reactivity to SARS-CoV-2
  • There is a growing body of research documenting pre-existing immunological responses to SARS-CoV-2 may force pandemic planners to revisit some of their foundational assumptions about how to measure population susceptibility and monitor the extent of epidemic spread.
Submitted by Brian Armstrong
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11
A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency
Published: Sep 2020
  • The authors show that vitamin D deficiency can explain every major risk factor, including the mystery of why children seem relatively protected and why males, the elderly, and people with naturally melanin-rich skin are especially vulnerable
  • “COVID-19” is the MeSH term for SARS-CoV-2 disease, coronavirus 2019, COVID-19, and derivative terms - which were used for the literature search associated with this review
Submitted by Patrick Joyce
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11
A ketogenic diet helps to protect older mice from the age-induced risk of COVID
From Paper: Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model
Authors:
Ryu, Seungjin, et al
Published: Sep 2020
  • The increased severity of infection in aged animals involved increased inflammasome activation and loss of {gamma}{delta} T cells that was corrected by ketogenic diet
  • This study developed a model of natural murine beta coronavirus infection with mouse hepatitis virus strain MHV-A59 that recapitulated the majority of clinical hallmarks of COVID-19 - then explored how a ketogenic diet influenced the progression of this mouse COVID-19 model
Submitted by Will McBurnie
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