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Trending Papers in medical sciences

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6
Reduced heart rate variability is associated with vulnerability to depression
Published: Sep 2020
  • The results suggest that reduced HRV is likely to be implicated in the risk of developing full-blown depression, rather than being a mere correlate of current depressive state
  • Self-reported psychological measures and three-minute resting-state ECG were collected in two at-risk populations [group with dysphoria (n = 27), group with past depression (n = 16)] and in a control group (n = 25)
Submitted by Patrick Joyce
Slide 1 of 1
8
Stem cells administered via the nose can help treat schizophrenia
From Paper: Mesenchymal stem cells derived extracellular vesicles improve behavioral and biochemical deficits in a phencyclidine model of schizophrenia
Authors:
Tsivion-Visbord, Hadas, et al
Published: Sep 2020
  • MSCs-EVs treatment significantly restored a normal social pattern in these mice, as shown in a heat map representation of the time spent exploring the chambers and by quantitative measurement of that activity
  • The intranasal route for administration of drugs is especially advantageous for CNS access, convenient to use and can improve patient compliance. Another advantage of using MSCs-EVs is their ability to migrate to the site of injury, demonstrated in studies done by our research group and by others
Submitted by Will McBurnie
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16
82% of alcohol-related health studies were either authored or funded by alcohol companies
From Paper: Declared funding and authorship by alcohol industry actors in the scientific literature: a bibliometric study
Published: Sep 2020
  • This study investigates the extent and type of scientific research 1918–2019 which was supported by the alcohol industry, including alcohol companies themselves and other organizations, such as trade associations
  • The analysis included 13 481 unique records, 11 014 (82%) were authored or funded by alcohol companies and 2488 (18%) were authored or funded by other organizations
Submitted by Patrick Joyce
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3
Dengue fever may provide some immunity to COVID-19
From Paper: How super-spreader cities, highways, hospital bed availability, and dengue fever influenced the COVID-19 epidemic in Brazil
Published: Sep 2020
  • The inverse correlation between COVID-19 and dengue fever was further observed in a sample of countries around Asia and Latin America, as well as in islands in the Pacific and Indian Oceans
  • The authors identified negative correlations between COVID-19's incidence, infection growth rate, and mortality to the percentage of people with antibody (IgM) levels for dengue fever in each of the country's states
Submitted by Will McBurnie
Slide 1 of 1
5
The development of an algorithm that can help optimize treatment for adolescent depression between pharmaceuticals and cognitive behavioral therapy
From Paper: Developing a data-driven algorithm for guiding selection between cognitive behavioral therapy, fluoxetine, and combination treatment for adolescent depression
Authors:
Meredith Gunlicks-Stoessel, Bonnie Klimes-Dougan, Adrienne VanZomeren, Sisi Ma
Published: Sep 2020
  • This model successfully stratified patients according to their responsiveness to a SSRI vs cognitive behavior therapy vs. a combination of the two
  • In this paper, machine-learning was applied to a wide range of demographic, clinical, and psychosocial data collected in treatment of adolescents with depression study (TADS) to build a model to predict overall treatment response after 12 weeks
Submitted by Patrick Joyce
Slide 1 of 1
4
Low to moderate alcohol drinking is associated with better cognition in older age than complete abstinence from alcohol
From Paper: Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults
Published: Jun 2020
  • Weekly alcohol consumption had U-shaped relationships with the cognitive functions assessed, with the strongest associations with better cognitive functions at a dosage of 10 to 14 drinks per week for all participants
  • Low to moderate drinking was associated with consistently high cognitive function trajectories. Cognitive test scores at the baseline middle-aged assessment were relatively high and remained high at each subsequent assessment. In addition, there was a decreased rate of cognitive decline with age for middle-aged or older US adults for low to moderate drinkers
Submitted by Patrick Joyce
Slide 1 of 1
8
A review of the common neural circuits and molecular signaling pathways between autism spectrum disorder and drug addiction
From Paper: Autism Spectrum Disorders and Drug Addiction: Common Pathways, Common Molecules, Distinct Disorders?
Published: Feb 2016
  • Rodent models of ASDs and addiction obviously lack the nuance and specificity of the clinical condition, but some interesting similarities in repetitive behavioral patterns seem to suggest common striatal circuitry may be affected in both disorders
  • Given this established link between addiction and D1-medium spiny neuron in the nucleus accumbens, it is interesting that recent reports linked these same cells to social behavior in wild-type mice, as well as repetitive behavior in mice carrying ASD-associated mutations
Submitted by Will McBurnie
Slide 1 of 1
8
The FIFA 11+ dynamic warm-up routine reduced the risk of injury in soccer players by 30%
From Paper: The FIFA 11+ injury prevention program for soccer players: a systematic review
Published: Nov 2017
  • This result corroborates data from other studies regarding the effectiveness of the FIFA 11+ program for injury prevention in soccer players
  • The FIFA 11+ program reduced injuries in soccer players by 30%, with an estimated relative risk of 0.70 (95% confidence interval, 0.52–0.93, p = 0.01)
Submitted by Patrick Joyce
Slide 1 of 1
5
People with low vitamin D levels are more likely to test positive for SARS-COV-2 infection
From Paper: SARS-CoV-2 positivity rates associated with circulating 25-hydroxyvitamin D levels
Published: Sep 2020
  • These results provide further rationale to explore the role of vitamin D supplementation in reducing the risk for SARS-CoV-2 infection and COVID-19 disease
  • The SARS-CoV-2 positivity rate was higher in the 39,190 patients with “deficient” 25(OH)D values (<20 ng/mL) (12.5%, 95% C.I. 12.2–12.8%) than in the 27,870 patients with “adequate” values (30–34 ng/mL) (8.1%, 95% C.I. 7.8–8.4%) and the 12,321 patients with values ≥55 ng/mL (5.9%, 95% C.I. 5.5–6.4%)
Submitted by Patrick Joyce
Slide 1 of 1
10
A Basic Review of the Preliminary Evidence That COVID-19 Risk and Severity Is Increased in Vitamin D Deficiency
Published: Sep 2020
  • The authors show that vitamin D deficiency can explain every major risk factor, including the mystery of why children seem relatively protected and why males, the elderly, and people with naturally melanin-rich skin are especially vulnerable
  • “COVID-19” is the MeSH term for SARS-CoV-2 disease, coronavirus 2019, COVID-19, and derivative terms - which were used for the literature search associated with this review
Submitted by Patrick Joyce
Slide 1 of 1
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