Conclusions Data from four nationally representative birth cohorts suggests that alcohol use during the pandemic increased in up to thirty percent of individuals. Hazardous drinking was observed in up to ten percent of respondents. Stress and inhibitory control were related to this but effects were age dependent. Governments should carefully consider the impact of personality and stress that may affect alcohol consumption in at-risk individuals.
The results showed a positive association between mentally passive sedentary behavior and risk of depression, and the increment of time spent on sedentarily watching television could increase the risk of depression
When stratified by specific sedentary behavior, we found that watching television was positively associated with the risk of depression, whereas using a computer was statistically non-significant
The authors believe this study suggests that the abnormalities in the composition of gut microbiota contribute to the pathogenesis of schizophrenia partially through the manipulation of tryptophan–kynurenine metabolism
The results revealed that transplantation of fecal microbiota from schizophrenic patients into antibiotic-treated mice caused behavioral abnormalities such as psychomotor hyperactivity, impaired learning and memory in the recipient animals
Schizophrenic individuals exhibited a set of genes significantly upregulated in the DLPFC (BA46) (XPO1 and DICER1), the associative striatum (XPO1) and in the cerebellum (DROSHA, NUP153, DICER1, and AGO2)
The results showed distinct altered expression patterns of the miRNA biomachinery coding genes in the brain tissues of schizophrenic individuals (with the exception of the anterior prefrontal, parietal and superior temporal cortices in which no alterations were found)
The results demonstrated the efficacy of psilocybin-assisted therapy in producing large, rapid, and sustained antidepressant effects among patients with major depressive disorder
In this study 27 participants were randomized, of whom 24 (89%) completed the intervention as well as the post-session assessments at weeks 1 and 4; 13 were randomized to the immediate treatment group and 11 to the delayed treatment group
Preliminary findings on the potential psychological mechanisms associated with therapeutic benefits indicate similarities with mindfulness-based therapy. Ayahuasca appears to enhance self- acceptance and decentering, crucial aspects associated with psychotherapeutic treatment outcome in several psychiatric disorders.
From a neural perspective, neuroimaging studies after an ayahuasca intake have reported activation in areas associated with emotional processing and memory formation. These results suggest that similarly to exposure therapies, ayahuasca allows reviewing emotional events, but with increased vividness and sense of “reality”.
The results showed that moderate lifetime alcohol intake (i.e., 1–13 standard drinks [SDs]/week) was significantly associated with lower amyloid deposition compared to no drinking
This study is a cross-sectional analyses of the baseline data from 414 individuals who participated in the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), an ongoing prospective cohort study
The results identified several genetic markers potentially associated with TRD and with antidepressant treatment response in a large population of individuals using self-reported outcomes
This study was identified novel genetic variants associated with response to classes of antidepressant therapy to improve our understanding of a potential genetic basis of antidepressant treatment response and to differentiate TRD from non-TRD (NTRD)
People who had recovered, including those no longer reporting symptoms, exhibited significant cognitive deficits when controlling for age, gender, education level, income, racial-ethnic group and pre-existing medical disorders
There were of substantial effect size for people who had been hospitalized for severe COVID-19, and also for those mild asymptomatic cases