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Trending Papers in psychiatry

Poor inhibitory control and stress as risk-factors for alcohol (mis)use during the COVID-19 pandemic in the UK: a national cross-sectional study utilising data from four birth cohorts
Published: Oct 2020
  • Conclusions Data from four nationally representative birth cohorts suggests that alcohol use during the pandemic increased in up to thirty percent of individuals. Hazardous drinking was observed in up to ten percent of respondents. Stress and inhibitory control were related to this but effects were age dependent. Governments should carefully consider the impact of personality and stress that may affect alcohol consumption in at-risk individuals.
"Mentally-passive" sedentary behaviors like watching TV contribute to depression risk. Sedentary behaviors like using a computer do not increase risk
From Paper: Sedentary behaviors and risk of depression: a meta-analysis of prospective studies
Published: Feb 2020
  • The results showed a positive association between mentally passive sedentary behavior and risk of depression, and the increment of time spent on sedentarily watching television could increase the risk of depression
  • When stratified by specific sedentary behavior, we found that watching television was positively associated with the risk of depression, whereas using a computer was statistically non-significant
DNA methylation at birth can be used as a biomarker for ADHD symptoms
From Paper: Association between DNA methylation and ADHD symptoms from birth to school age: A prospective meta-analysis
Published: Oct 2019
  • Interestingly methylation can only be used as a biomarker for ADHD in infants. At school-age no CpG sites were associated with ADHD
  • The authors state that the results suggest that cord blood DNA methylation is a marker for some of the ADHD risk factors before birth or functions as a potential mediator of these risk factors
Retrieved from biorxiv
Transplantation of gut microbiota from a patient with schizophrenia causes schizophrenia-like symptoms in mice
From Paper: Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice
Published: Nov 2020
  • The authors believe this study suggests that the abnormalities in the composition of gut microbiota contribute to the pathogenesis of schizophrenia partially through the manipulation of tryptophan–kynurenine metabolism
  • The results revealed that transplantation of fecal microbiota from schizophrenic patients into antibiotic-treated mice caused behavioral abnormalities such as psychomotor hyperactivity, impaired learning and memory in the recipient animals
Patrick Joyce
There is widespread disruption of microRNA production in patients diagnosed with schizophrenia
From Paper: Widespread transcriptional disruption of the microRNA biogenesis machinery in brain and peripheral tissues of individuals with schizophrenia
Published: Nov 2020
  • Schizophrenic individuals exhibited a set of genes significantly upregulated in the DLPFC (BA46) (XPO1 and DICER1), the associative striatum (XPO1) and in the cerebellum (DROSHA, NUP153, DICER1, and AGO2)
  • The results showed distinct altered expression patterns of the miRNA biomachinery coding genes in the brain tissues of schizophrenic individuals (with the exception of the anterior prefrontal, parietal and superior temporal cortices in which no alterations were found)
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A randomized clinical trial shows that Psilocybin is an effective treatment for major depressive disorder
From Paper: Agg older than me and my friends
Published: Jan 1960
  • The results demonstrated the efficacy of psilocybin-assisted therapy in producing large, rapid, and sustained antidepressant effects among patients with major depressive disorder
  • In this study 27 participants were randomized, of whom 24 (89%) completed the intervention as well as the post-session assessments at weeks 1 and 4; 13 were randomized to the immediate treatment group and 11 to the delayed treatment group
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Ayahuasca: Pharmacology, neuroscience and therapeutic potential
From Paper: (PDF) Ayahuasca: Pharmacology, neuroscience and therapeutic potential
Published: Mar 2016
  • Preliminary findings on the potential psychological mechanisms associated with therapeutic benefits indicate similarities with mindfulness-based therapy. Ayahuasca appears to enhance self- acceptance and decentering, crucial aspects associated with psychotherapeutic treatment outcome in several psychiatric disorders.
  • From a neural perspective, neuroimaging studies after an ayahuasca intake have reported activation in areas associated with emotional processing and memory formation. These results suggest that similarly to exposure therapies, ayahuasca allows reviewing emotional events, but with increased vividness and sense of “reality”.
Moderate alcohol consumption is associated with lower levels of a marker for Alzheimer's Disease
From Paper: Association of moderate alcohol intake with in vivo amyloid-beta deposition in human brain: A cross-sectional study
Kim, Jee Wook, et al
Published: Feb 2020
  • The results showed that moderate lifetime alcohol intake (i.e., 1–13 standard drinks [SDs]/week) was significantly associated with lower amyloid deposition compared to no drinking
  • This study is a cross-sectional analyses of the baseline data from 414 individuals who participated in the Korean Brain Aging Study for Early Diagnosis and Prediction of Alzheimer’s Disease (KBASE), an ongoing prospective cohort study
A person's genes indicate if they are likely to respond to a specific antidepressant drug
From Paper: Genome-wide association studies of antidepressant class response and treatment-resistant depression
Qingqin S. Li, Chao Tian, David Hinds
Published: Oct 2020
  • The results identified several genetic markers potentially associated with TRD and with antidepressant treatment response in a large population of individuals using self-reported outcomes
  • This study was identified novel genetic variants associated with response to classes of antidepressant therapy to improve our understanding of a potential genetic basis of antidepressant treatment response and to differentiate TRD from non-TRD (NTRD)
Cognitive deficits in people who have recovered from COVID-19
From Paper: Cognitive deficits in people who have recovered from COVID-19 relative to controls: An N=84,285 online study
  • People who had recovered, including those no longer reporting symptoms, exhibited significant cognitive deficits when controlling for age, gender, education level, income, racial-ethnic group and pre-existing medical disorders
  • There were of substantial effect size for people who had been hospitalized for severe COVID-19, and also for those mild asymptomatic cases
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