A defect in a single transcription factor that regulates the balanced differentiation of GABAergic and glutamatergic neurons in the developing anterior brainstem, leads to several endophenotypes of ADHD
Amphetamine-induced dopamine release and amphetamine-induced place preference were normal in Tal1cko mice. Increased dopamine signaling failed to stimulate the locomotor activity of the Tal1cko mice, but instead alleviated their hyperactivity
CellRank is able to predict a novel dedifferentiation trajectory during regeneration after lung injury, which we follow up experimentally by confirming the existence of previously unknown intermediate cell states.
The results show that CellRank automatically detects initial, intermediate and terminal populations, predicts fate potentials, and visualizes continuous gene expression trends along individual lineages in Pancreas cell development
The results revealed that quiescent satellite cells associated with myofibers could be activated by factors leaked from damaged myofibers that promote activation and proliferation in coordination with mitogens during muscle regeneration
To determine whether activated satellite cells are reversible to the quiescent-like state without cell division, individual muscle fibers were freshly isolated cultured with or without damaged myofibers for 48 hours
The compound, BIO-133, is a gel polymer with a light refraction index identical to water. This property gives the microscope better resolution compared to other mediums that allow for microfluidic imaging
BIO-133 enabled the immobilization of 1) Drosophila tissue, allowing the authors to track membrane puncta in pioneer neurons, and 2) C. elegans, which allowed the authors to image and inspect fine neural structure and to track pan-neuronal calcium activity over hundreds of volumes
Our analysis demonstrates that KRT8 is (1) differentially expressed in several cancers across all molecular modalities and (2) may be useful as a biomarker to identify patients that should be further tested for cancer.
Detectable KRT8 in serum as measured by ELISA distinguished patients with pancreatic cancer from healthy controls with an AUROC=0.94.
σ1R has a powerful capability to fine-tune cells’ electrical activity and calcium homeostasis—a regulatory power that appears to favor cell survival in pathological contexts such as stroke or neurodegenerative diseases
One of the most striking findings discussed in this review is that σ1R, through a common mechanism, i.e., the chaperoning of voltage-gated K+ channels, is involved in both neuronal response to cocaine and cancer cell response to tumor microenvironment
The results demonstrate telomere shortening with age in the lungs of wild-type mice, reaching at old ages values similar to those of young G3 Tert−/− mice
Mice with a mutation in TERT (telomerase gene) and a control, mice without a TERT mutation, were both given telomerase gene therapy and then assessed for telomere shortening and lung fibrosis at various time points throughout their lives