We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1, PIK3CA, ARID1A and KRAS and novel mutations in the SWI/SNF chromatin remodelling complex gene ARID5B. A subset of endometrioid tumours that we identified had a markedly increased transversion mutation frequency and newly identified hotspot mutations in POLE. Our results classified endometrial cancers into four categories: POLE ultramutated, microsatellite instability hypermutated, copy-number low, and copy-number high. Uterine serous carcinomas share genomic features with ovarian serous and basal-like breast carcinomas. We demonstrated that the genomic features of endometrial carcinomas permit a reclassification that may affect post-surgical adjuvant treatment for women with aggressive tumours.
1. No data showed the harmful effects of NAIs on humans/animals.
2. Negative air ions have multiple health benefits on humans/animals. It might inhibit the growth and/or kill some of microorganisms and promote plant development
Norbert Pardi, Michael J. Hogan, Frederick W. Porter, Drew Weissman
Published: Apr 2018
mRNA cancer vaccines have shown some promising results in clinical trials displaying antigen-specific T cell responses and prolonged disease-free survival in some cases
mRNA vaccines have elicited potent immunity against infectious disease targets in animal models of influenza virus, Zika virus, rabies virus and others, especially in recent years, using lipid-encapsulated or naked forms of sequence-optimized mRNA
Cutimycin, a thiopeptide antibiotic produced by the skin commensal Cutibacterium acnes, reduces Staphylococcus colonization of human skin hair follicles.Cutimycin, a thiopeptide antibiotic produced by the skin commensal Cutibacterium acnes, reduces Staphylococcus colonization of human skin hair follicles.
The genetic gains in protein yield increased by about 8.57% in cows with test records and 2.8% in bulls with progeny records over gains with the conventional best linear unbiased prediction (CBLUP) method, while gains were increased by about 23.4% for heifers without test records and 34.6% for bulls without progeny records
With the development of DNA analysis technology and the reduced cost of single nucleotide polymorphism (SNP) chip analysis, a lot of research has been conducted on the genomic selection of dairy cattle
Raphael Mrode, Julie M. K Ojango, A. M. Okeyo, Joram M. Mwacharo
Published: Jan 2019
Genomic selection (GS) has resulted in rapid rates of genetic gains especially in dairy cattle in developed countries resulting in a higher proportion of genomically proven young bulls being used in breeding.
The basic principle of GS is that single nucleotide polymorphisms (SNPs) are assumed to be at linkage disequilibrium (LD) with QTLs in the genome.
Therefore, the use of SNPs as markers enables all QTLs in the genome to be indirectly identified through the mapping of chromosome segments defined by adjacent SNPs.
The implementation of GS usually involves estimating the SNP effects in a reference population which consists of individuals with phenotypic records and genotypes.
The observed number of alleles in this study suggests that the locus is not suitable for the genetic analysis of the three Nigerian goats; or, the methodology used might not have been appropriate at the β-lactoglobulin gene locus
The results reveal the presence of very low or no genetic difference among the goat population at the β-lactoglobulin locus