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Trending Papers in quantum biology

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432
From Paper: The Quantum Biology of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics
Published: Dec 2016
From Paper: The Quantum Biology of Reactive Oxygen Species Partitioning Impacts Cellular Bioenergetics
Published: Dec 2016
  • The RP spin dynamics are governed by internal magnetic interactions, usually electron-nuclear hyperfine interactions (HFIs) and applied magnetic fields
  • These results provide fundamental insights into the role of the RPM in ROS redox biology and cellular bioenergetics, revealing a new example of quantum biology
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Patrick Joyce
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Patrick Joyce
387
From Paper: Identification and characterization of diverse coherences in the Fenna–Matthews–Olson complex
Authors: Thyrhaug, Erling, et al
Published: Jul 2018
From Paper: Identification and characterization of diverse coherences in the Fenna–Matthews–Olson complex
Authors: Thyrhaug, Erling, et al
Published: Jul 2018
  • The presence of such states suggests that vibronic coupling is relevant for photosynthetic energy transfer.
  • We show that the long-lived QBs are exclusively vibrational in origin, whereas the dephasing of the electronic coherences is completed within 240 fs even at 77 K. We further find that specific vibrational coherences are produced via vibronically coupled excited states.
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Patrick Joyce
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Patrick Joyce
216
From Paper: On the Chameleonic Behaviour of Cholesterol through a Fractal/Multifractal Model
Published: Jan 2020
From Paper: On the Chameleonic Behaviour of Cholesterol through a Fractal/Multifractal Model
Published: Jan 2020
  • This model can be used to analyze biological dynamics at nanoscale, with implications in various molecular medicine fields
  • The dynamics equations in the form of fractal/multifractal-type geodesics are obtained, and from here, in the stationary case, a fractal/multifractal tunneling effect for systems with spontaneous symmetry breaking is analyzed
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Patrick Joyce
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Patrick Joyce
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Authors: D. Aiello, Clarice, et al
Published: Aug 2020
Authors: D. Aiello, Clarice, et al
Published: Aug 2020
  • Observations of the CISS effect suggest unique opportunities for spin control and for the design and fabrication of room-temperature quantum devices from the bottom up, with atomic-scale precision
  • This forward-looking review article provides a survey of the experimental and theoretical fundamentals of chiral-influenced quantum effects and presents a vision for their future role in enabling room-temperature quantum technologies.
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Patrick Joyce
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Authors: Abdallah Barjas Qaswal
Published: Dec 2019
Authors: Abdallah Barjas Qaswal
Published: Dec 2019
The myelin sheath facilitates action potential conduction along the axons, however, the mechanism by which myelin maintains the spatiotemporal fidelity and limits the hyperexcitability among myelinated neurons requires further investigation. Therefore, in this study, the model of quantum tunneling of potassium ions through the closed channels is used to explore this function of myelin. According to the present calculations, when an unmyelinated neuron fires, there is a probability of 9.15 × 10 − 4 that it will induce an action potential in other unmyelinated neurons, and this probability varies according to the type of channels involved, the channels density in the axonal membrane, and the surface area available for tunneling. The myelin sheath forms a thick barrier that covers the potassium channels and prevents ions from tunneling through them to induce action potential. Hence, it confines the action potentials spatiotemporally and limits the hyperexcitability. On the other hand, lack of myelin, as in unmyelinated neurons or demyelinating diseases, exposes potassium channels to tunneling by potassium ions and induces the action potential. This approach gives different perspectives to look at the interaction between neurons and explains how quantum physics might play a role in the actions occurring in the nervous system.
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Patrick Joyce
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Published: Apr 2020
Published: Apr 2020
Proton-coupled transporters use transmembrane proton gradients to power active transport of nutrients inside the cell. High-resolution structures often fail to capture the coupling between proton and ligand binding, and conformational changes associated with transport. We combine HDX-MS with mutagenesis and MD simulations to dissect the molecular mechanism of the prototypical transporter XylE. We show that protonation of a conserved aspartate triggers conformational transition from outward- facing to inward-facing state. This transition only occurs in the presence of substrate xylose, while the inhibitor glucose locks the transporter in the outward-facing state. MD simulations corroborate the experiments by showing that only the combination of protonation and xylose binding, and not glucose, sets up the transporter for conformational switch. Overall, we demonstrate the unique ability of HDX-MS to distinguish between the conformational dynamics of inhibitor and substrate binding, and show that a specific allosteric coupling between substrate binding and protonation is a key step to initiate transport.
Retrieved from biorxiv
Retrieved from biorxiv