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Modification of biologically active amides and amines with fluorine-containing heterocycles.

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Sokolov, V.B., Aksinenko, A.Y., Goreva, T.V. et al. Modification of biologically active amides and amines with fluorine-containing heterocycles.

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Abstract

A synthetic approach to the modification of the drug “riluzole” with pharmacologically active fragments such as carbazole, tetrahydrocarbazole, phenothiazine, and aminothiophene, based on the copper-catalyzed alkyne-azide 1,3-dipolar cycloaddition of azide-containing pharmacophores with “riluzole” decorated with 5-trifluoromethylhydantoin, has been suggested.
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