Intermetallic nanocrystals are a large family of emerging materials with extensive applications in many fields. Yet, a generalized synthetic method for intermetallic nanocrystals is lacking. Here, we report the development of a colloidal synthesis method based on amalgamation of monometallic nanocrystal seeds with low–melting point metals. We use this approach to achieve crystalline and compositionally uniform intermetallic nanocrystals of Au-Ga, Ag-Ga, Cu-Ga, Ni-Ga, Pd-Ga, Pd-In, and Pd-Zn compounds. We demonstrate both compositional tunability across the phase spaces (e.g., AuGa2, AuGa, Au7Ga2, and Ga-doped Au), size tunability (e.g., 14.0-, 7.6-, and 3.8-nm AuGa2), and size uniformity (e.g., 5.4% size deviations). This approach makes it possible to systematically achieve size- and composition-controlled intermetallic nanocrystals, opening up a multitude of possibilities for these materials. Seed amalgamation reaction unlocks a large family of intermetallic nanocrystals with excellent size and composition control. Seed amalgamation reaction unlocks a large family of intermetallic nanocrystals with excellent size and composition control.