A defect in a single transcription factor that regulates the balanced differentiation of GABAergic and glutamatergic neurons in the developing anterior brainstem, leads to several endophenotypes of ADHD
Amphetamine-induced dopamine release and amphetamine-induced place preference were normal in Tal1cko mice. Increased dopamine signaling failed to stimulate the locomotor activity of the Tal1cko mice, but instead alleviated their hyperactivity
CellRank is able to predict a novel dedifferentiation trajectory during regeneration after lung injury, which we follow up experimentally by confirming the existence of previously unknown intermediate cell states.
The results show that CellRank automatically detects initial, intermediate and terminal populations, predicts fate potentials, and visualizes continuous gene expression trends along individual lineages in Pancreas cell development
The identified inhibitors for open data sharing mostly relate to legislation and regulation, facilitating conditions, and expected performance, in the sense that openly sharing research data can lead to worse performance
Most drivers for openly sharing research data are related to personal and intrinsic motivations
The authors used Wikipedia to formulate knowledge on growing networks of articles and their hyperlinked inter-relations
This paper demonstrates that scientific concept networks grow not by expanding from their core but rather by creating and filling knowledge gaps, a process which produces discoveries that are more frequently awarded Nobel prizes than others