RH Logo
Hubs
About
Live
Leaderboard

Trending Hubs

Most Reputable Users

Trending Papers on ResearchHub

Trending
Today
201
Published: Aug 2020
Published: Aug 2020
  • The list of underlying conditions relevant to COVID-19 was determined by mapping the conditions listed in GBD 2017 to those listed in guidelines published by WHO and public health agencies in the UK and the USA.
Author Profile Avatar
ayotune adebayo
Author Profile Avatar
ayotune adebayo
205
Published: Jan 2021
Published: Jan 2021
  • The contribution of humoral immunity in the process of COVID-19 recovery and the role of ACE2 in virus infectivity and pathogenesis has been discussed.
Author Profile Avatar
ayotune adebayo
Author Profile Avatar
ayotune adebayo
456
From Paper: Blocking the Rac1-TRPC5 pathway protects human podocytes
Published: Jan 2021
From Paper: Blocking the Rac1-TRPC5 pathway protects human podocytes
Published: Jan 2021
Podocyte injury and the appearance of proteinuria are key features of several progressive kidney diseases. Genetic deletion or selective inhibition of TRPC5 channels with small-molecule inhibitors protects podocytes in rodent models of disease, but less is known about the human relevance and translatability of TRPC5 inhibition. Here, we investigate the effect of TRPC5 inhibition in puromycin aminonucleoside (PAN)-treated human iPSC-derived podocytes and kidney organoids. We first established that systemic administration of the TRPC5-specific blocker AC1903 was sufficient to protect podocyte cytoskeletal proteins and suppress proteinuria in PAN-induced nephrosis in rats, an established model of podocyte injury and progressive kidney disease. PAN treatment also triggered the Rac1-TRPC5 injury pathway in human iPSC-derived podocytes and kidney organoids. TRPC5 current was recorded in human iPSC-derived podocytes, and was blocked by AC1903. The TRPC5 blocker also reversed the effects of PAN-induced injury in human podocytes in both 2D and 3D culture systems. Taken together, these results revealed the relevance of the TRPC5-Rac1 pathway in human kidney tissue highlighting the potential of this therapeutic strategy for patients.
Author Profile Avatar
Chukwuma Chidera
Slide 1 of 1
  • Paper Preview Page 1
Author Profile Avatar
Chukwuma Chidera
203
Published: Jun 2021
Published: Jun 2021
  • Tocilizumab has been proposed as a treatment for the new disease COVID-19, however, there is not enough scientific evidence to support this treatment. The objective of this study is to analyze whether the use of tocilizumab is associated with respiratory improvement and a shorter time to discharge in patients with COVID-19 and lung involvement.
Author Profile Avatar
ayotune adebayo
Author Profile Avatar
ayotune adebayo
203
Published: Nov 2020
Published: Nov 2020
  • Recent studies have suggested that proton pump inhibitor (PPI) use may increase the risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and worsen the course COVID-19.
Author Profile Avatar
ayotune adebayo
Author Profile Avatar
ayotune adebayo
203
Published: Jan 2021
Published: Jan 2021
  • Serum from recovered patients discloses a different composition than that from patients with severe disease. • Latent autoimmunity and anti–IFN–α antibodies are observed in COVID-19. • COVID-19 CP induces an early but transient effect on antibody and cytokine profile of patients with severe disease . • CP decreases activated and effector T cells, and increases memory immune cells. • CP reduces the IL-6/IFN-γ and IL-6/IL-10 ratios.
Author Profile Avatar
ayotune adebayo
Author Profile Avatar
ayotune adebayo
305
From Paper: <i>ENHANCED GRAVITROPISM 2</i> encodes a STERILE ALPHA MOTIVE containing protein that controls root growth angle in barley and wheat
Published: Jan 2021
From Paper: <i>ENHANCED GRAVITROPISM 2</i> encodes a STERILE ALPHA MOTIVE containing protein that controls root growth angle in barley and wheat
Published: Jan 2021
The root growth angle defines how roots grow towards the gravity vector and is among the most important determinants of root system architecture. It controls water uptake capacity, nutrient use efficiency, stress resilience and as a consequence yield of crop plants. We demonstrated that the ( ) mutant of barley exhibits steeper root growth of seminal and lateral roots and an auxin independent higher responsiveness to gravity compared to wild type plants. We cloned the gene by a combination of bulked segregant analysis and whole genome sequencing. Subsequent validation experiments by an independent CRISPR/Cas9 mutant allele demonstrated that encodes a STERILE ALPHA MOTIF domain containing protein. hybridization experiments illustrated that is expressed from the root cap to the elongation zone. Subcellular localization experiments revealed that localizes to the nucleus and cytoplasm. We demonstrated the evolutionary conserved role of in root growth angle control between barley and wheat by knocking out the orthologs in the A and B genomes of tetraploid durum wheat. By combining laser capture microdissection with RNA-seq, we observed that seven expansin genes were transcriptionally downregulated in the elongation zone. This is consistent with a role of in this region of the root where the effect of gravity sensing is executed by differential cell elongation. Our findings suggest that is an evolutionary conserved regulator of root growth angle in barley and wheat that could be a valuable target for root-based crop improvement strategies in cereals.
Author Profile Avatar
Chukwuma Chidera
Slide 1 of 1
  • Paper Preview Page 1
Author Profile Avatar
Chukwuma Chidera
208
Published: Jan 2018
Published: Jan 2018
  • Presently, the bottleneck in the deployment of high-throughput sequencing technology is the ability to analyse the increasing amount of data produced in a fit-for-purpose manner. The field of microbial bioinformatics is thriving and quickly adapting to technological changes, which creates difficulties for nonbioinformaticians in following the complexity and increasingly obscure jargon of this field.
Author Profile Avatar
ayotune adebayo
Author Profile Avatar
ayotune adebayo
206
Published: May 2017
Published: May 2017
  • Introduction of the RNA Bioinformatics Center (RBC). • Summary of tools and services provided by the RBC. • Description of the Freiburg Galaxy Server.
Author Profile Avatar
ayotune adebayo
Author Profile Avatar
ayotune adebayo
205
Published: Jun 2017
Published: Jun 2017
  • The distinctive features of the methods implemented are ontology-based automated adaptation to third-party data sources from various application domains and to specifics of the visualization problems as well as multiplatform portability of the software solution.
Author Profile Avatar
ayotune adebayo
Author Profile Avatar
ayotune adebayo
Load More Papers
Trending Hubs