Abstract

Medical research has evolved, from individual expert described opinions and techniques, toscientifically designed methodology-based studies. Evidence-based medicine (EBM) wasestablished to re-evaluate medical facts and remove various myths in clinical practice. Researchmethodology is now protocol based with predefined steps. Studies were classified based on themethod of collection and evaluation of data. Clinical study methodology now needs to complyto strict ethical, moral, truth, and transparency standards, ensuring that no conflict of interest isinvolved. A medical research pyramid has been designed to grade the quality of evidence andhelp physicians determine the value of the research. Randomised controlled trials (RCTs) havebecome gold standards for quality research. EBM now scales systemic reviews and meta-analysesat a level higher than RCTs to overcome deficiencies in the randomised trials due to errors inmethodology and analyses