Proposal

Proposal

Drafts

DCTN1 Reduction: Testing the Early Neuronal Sterol Response | ResearchHub

Proposal

Proposal

Drafts

Peer review for $150

3

RF

ResearchHub Foundation

DCTN1 Reduction: Testing the Early Neuronal Sterol Response

ResearchHub Foundation

ResearchHub Foundation

Posted Oct 22, 2026Testing the DCTN1–Cholesterol Hypothesis in the Wet Lab

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Proposes a cautious iPSC-neuron (NGN2+CRISPRi) replication of the AI-derived DCTN1-sterol transcriptional signal using two guides, rescue, and preregistered RT-qPCR of a sterol panel for $44,220. Fits RFP question 1 (reproducibility) with strong rigor and open-science commitments, but deliberately does not test transport, flux, or Perry syndrome causality, and no executing lab or iPSC line is yet identified.

Rigorous controls
Preregistered analysis
No executing lab
Limited mechanistic reach