Metoposaurids are a widespread and ubiquitous constituent of Late Triassic non-marine paleoenvironments. In North America, this group is practically the only large-bodied temnospondyl clade, and is particularly well documented from the American southwest and south-central regions (Arizona, New Mexico, Texas). However, metoposaurids are poorly documented from eastern North America, with fragmentary, doubtfully diagnostic historical material such as “ Dictyocephalus elegans ” Leidy, 1856 and “ Eupelor durus ” Cope, 1866. The Zions View (early Norian?) locality in Pennsylvania preserves more-complete material, which previous workers noted as belonging to “ Buettneria perfecta ” Case, 1922 (= Anaschisma browni Branson, 1905). However, the material has never been described in a fashion that characterizes the anatomy or that justifies the taxonomic assignment, yet it would represent the most complete material in eastern North America and a substantial expansion of this taxon's geographic range. Here we redescribe the Zions View metoposaurid material in detail, differentiating it from Calamops paludosus Sinclair, 1917, the only other Late Triassic temnospondyl from the eastern seaboard, and demonstrating confident affinities with A . browni . Our study is the first to properly justify the taxonomic referral, underscoring the broader importance of proper documentation of voucher specimens, especially for potential geographic outliers. Anaschisma browni is thus the most widely dispersed metoposaurid. Its easternmost documentation underscores the importance of the undersampled and understudied metoposaurid record on the eastern seaboard for understanding the development of a metoposaurid zone of exclusivity in North America and demonstrates the need for further exploration to refine conceptualizations of Late Triassic tetrapod evolution.

: The main role of platelets is to contribute to hemostasis. However, under pathophysiological conditions, platelet activation may lead to thrombotic events of cardiovascular diseases. Thus, anti-thrombotic treatment is important in patients with cardiovascular disease. This review focuses on a platelet receptor, a transmembrane protein, the Multidrug Resistance Protein 4, MRP4, which contributes to platelet activation by extruding endogenous molecules responsible for their activation and accumulation. The regulation of the intracellular concentration levels of these molecules by MRP4 turned to make the protein suspicious and, at the same time, an interesting regulatory factor of normal platelet function. Especially, the possible role of MRP4 in the excretion of xenobiotic and antiplatelet drugs such as aspirin is discussed, thus imparting platelet aspirin tolerance and correlating the protein with the ineffectiveness of aspirin antiplatelet therapy. Based on the above, this review finally underlines that the development of a highly selective and targeted strategy for platelet MRP4 inhibition will also lead to inhibition of platelet activation and accumulation.

In eukaryotes, genomic DNA is packaged into chromatin in the nucleus. The accessibility of DNA is dependent on the chromatin structure and dynamics, which essentially control DNA-related processes, including transcription, DNA replication, and repair. All of the factors that affect the structure and dynamics of nucleosomes, the nucleosome–nucleosome interaction interfaces, and the binding of linker histones or other chromatin-binding proteins need to be considered to understand the organization and function of chromatin fibers. In this review, we provide a summary of recent progress on the structure of chromatin fibers in vitro and in the nucleus, highlight studies on the dynamic regulation of chromatin fibers, and discuss their related biological functions and abnormal organization in diseases.