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Trending Papers in biomolecules

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From Paper: Lignin-Graft-Poly(lactic- <i>co</i> -glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis
Published: Apr 2020
From Paper: Lignin-Graft-Poly(lactic- <i>co</i> -glycolic) Acid Biopolymers for Polymeric Nanoparticle Synthesis
Published: Apr 2020
A lignin-graft-poly(lactic-co-glycolic) acid (PLGA) biopolymer was synthesized with two types of lignin (LGN), alkaline lignin (ALGN) and sodium lignosulfonate (SLGN), at different (A/S)LGN/PLGA ratios (1:2, 1:4, and 1:6 w/w). 1H NMR and Fourier-transform infrared spectroscopy (FT-IR) confirmed the conjugation of PLGA to LGN. The (A/S)LGN-graft-PLGA biopolymers were used to form nanodelivery systems suitable for entrapment and delivery of drugs for disease treatment. The LGN-graft-PLGA NPs were generally small (100–200 nm), increased in size with the amount of PLGA added, monodisperse, and negatively charged (−48 to −60 mV). Small-angle scattering data showed that particles feature a relatively smooth surface and a compact spherical structure with a distinct core and a shell. The core size and shell thickness varied with the LGN/PLGA ratio, and at a 1:6 ratio, the particles deviated from the core–shell structure to a complex internal structure. The newly developed (A/S)LGN-graft-PLGA NPs are proposed as a potential delivery system for applications in biopharmaceutical, food, and agricultural sectors.
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Brian Novak
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Brian Novak
183
From Paper: Integrative/Hybrid Modeling Approaches for Studying Biomolecules
Published: Feb 2020
From Paper: Integrative/Hybrid Modeling Approaches for Studying Biomolecules
Published: Feb 2020
  • Integrative/hybrid modeling combines input from multiple biophysical experiments. • Computation plays a crucial role in implementation of hybrid methods. • Advancements in cryo-EM and XL-MS have led to growth in hybrid modeling. • New methods such as XFEL hold promise for further development of hybrid methods.
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ayotune adebayo
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ayotune adebayo
102
From Paper: A novel technique for detection of biomolecules and its aqueous concentration using a double gate graphene field effect transistor
Published: Feb 2018
From Paper: A novel technique for detection of biomolecules and its aqueous concentration using a double gate graphene field effect transistor
Published: Feb 2018
  • A novel technique for detection of biomolecules has been proposed using adsorption on the gate material, Au (100). • Calculation of aqueous concentration of biomolecules present in the analyte solution introduced to the nanobiosensor. • The nanobiosensor exhibits excellent sensitivity in the sub threshold region. • Analytical model of the proposed nanobiosensor has been developed.
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ayotune adebayo
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ayotune adebayo
102
From Paper: Two-field transverse relaxation-optimized spectroscopy for the study of large biomolecules – An in silico investigation
Published: Dec 2020
From Paper: Two-field transverse relaxation-optimized spectroscopy for the study of large biomolecules – An in silico investigation
Published: Dec 2020
  • Optimal relaxation properties can be found at vastly different magnetic fields for two nuclear spins in the same spin system. • Two-field transverse relaxation optimized experiments can benefit from excellent relaxation properties for both nuclei within a single experiment. • Numerical simulations of 13C-19F pairs in aromatic side-chains of large proteins show an increase of sensitivity >x10 and better resolution with two-field methods.
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ayotune adebayo
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ayotune adebayo
102
From Paper: Preparation of biomolecule-polymer conjugates by grafting-from using ATRP, RAFT, or ROMP
Published: Nov 2019
From Paper: Preparation of biomolecule-polymer conjugates by grafting-from using ATRP, RAFT, or ROMP
Published: Nov 2019
  • Biomolecule-polymer conjugates represent an important class of macromolecular architectures that combine the advantageous properties inherent to both the biomolecule and synthetic polymer(s) appended to it.
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ayotune adebayo
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ayotune adebayo
191
From Paper: Enhancing multi-bioreactor platforms for automated measurements and reactive experiment control
Authors: Bertaux, François, et al
Published: Dec 2020
From Paper: Enhancing multi-bioreactor platforms for automated measurements and reactive experiment control
Authors: Bertaux, François, et al
Published: Dec 2020
  • They also tie these measured parameters to an optogenetic control mechanism - which changes gene expression using light. So, based on these measurements they increase or decrease gene expression, creating a feedback loop to improve culture conditions
  • Existing bioreactor setups are limited in their automated measurement capabilities because the measurement tools are usually bulky / standalone pieces of equipment so can't be used consistently over time.
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Arye Lipman
7
Authors: Biastoch, A., et al
Published: Jan 2011
Authors: Biastoch, A., et al
Published: Jan 2011
Vast amounts of methane hydrates are potentially stored in sediments along the continental margins, owing their stability to low temperature – high pressure conditions. Global warming could destabilize these hydrates and cause a release of methane (CH4) into the water column and possibly the atmosphere. Since the Arctic has and will be warmed considerably, Arctic bottom water temperatures and their future evolution projected by a climate model were analyzed. The resulting warming is spatially inhomogeneous, with the strongest impact on shallow regions affected by Atlantic inflow. Within the next 100 years, the warming affects 25% of shallow and mid-depth regions containing methane hydrates. Release of methane from melting hydrates in these areas could enhance ocean acidification and oxygen depletion in the water column. The impact of methane release on global warming, however, would not be significant within the considered time span.
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Luc Moser
163
From Paper: The context-dependent, combinatorial logic of BMP signaling
Published: Dec 2020
From Paper: The context-dependent, combinatorial logic of BMP signaling
Published: Dec 2020
  • Measuring ligand interactions in cells with different receptor profiles organizes BMP ligands into ‘equivalence groups’ (donuts) that vary w/receptor context, explain developmental phenomena, and can arise from ligand-receptor interactions.
  • Cell communication pathways use many ligand & receptor variants in combinations. Ligands can behave in weirdly “contextual” ways, replacing each other in one process but not another. What’s the logic+function of these pervasive bewildering systems?
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Arye Lipman
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