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Trending Papers in biomolecules

Relationship between serum bilirubin levels, urinary biopyrrin levels, and retinopathy in patients with diabetes
Published: Nov 2020
  • This negative association may be related to decreased production of bilirubin rather than increased consumption, given the positive association between bilirubin and biopyrrin levels.
Анатолий Касян
Distinguishing Single DNA Nucleotides Based on Their Times of Flight Through Nanoslits: A Molecular Dynamics Simulation Study
Published: Mar 2013
  • Distinguishing single DNA Nucleotides and it's importance . A molecular Dynamics Simulation Study
Electrophoretic Transport of Single DNA Nucleotides through Nanoslits: A Molecular Dynamics Simulation Study
Published: Aug 2015
There is potential for flight time based DNA sequencing involving disassembly into individual nucleotides which would pass through a nanochannel with two or more detectors. We performed molecular dynamics simulations of electrophoretic motion of single DNA nucleotides through 3 nm wide hydrophobic slits with both smooth and rough walls. The electric field (E) varied from 0.0 to 0.6 V/nm. The nucleotides adsorb and desorb from walls multiple times during their transit through the slit. The nucleotide–wall interactions differed due to nucleotide hydrophobicities and wall roughness which determined duration and frequency of nucleotide adsorptions and their velocities while adsorbed. Transient association of nucleotides with one, two, or three sodium ions occurred, but the mean association numbers (ANs) were weak functions of nucleotide type. Nucleotide–wall interactions contributed more to separation of nucleotide flight time distributions than ion association and thus indicate that nucleotide–wall interactions play a defining role in successfully discriminating between nucleotides on the basis of their flight times through nanochannels/slits. With smooth walls, smaller nucleotides moved faster, but with rough walls larger nucleotides moved faster due to fewer favorable wall adsorption sites. This indicates that roughness, or surface patterning, might be exploited to achieve better time-of-flight based discrimination between nucleotides.
Behavior of the ATP grasp domain of biotin carboxylase monomers and dimers studied using molecular dynamics simulations
Published: Feb 2011
The enzyme biotin carboxylase (BC) uses adenosine triphosphate (ATP) to carboxylate biotin and is involved in fatty acid synthesis. Structural evidence suggests that the B domain of BC undergoes a large hinge motion of ∼45° when binding and releasing substrates. Escherichia coli BC can function as a natural homodimer and as a mutant monomer. Using molecular dynamics simulations, we evaluate the free energy profile along a closure angle of the B domain of E. coli BC for three cases: a monomer without bound Mg2ATP, a monomer with bound Mg2ATP, and a homodimer with bound Mg2ATP in one subunit. The simulation results show that a closed state is the most probable for the monomer with or without bound Mg2ATP. For the dimer with Mg2ATP in one of its subunits, communication between the two subunits was observed. Specifically, in the dimer, the opening of the subunit without Mg2ATP caused the other subunit to open, and hysteresis was observed upon reclosing it. The most stable state of the dimer is one in which the B domain of both subunits is closed; however, the open state for the B domain without Mg2ATP is only approximately 2kBT higher in free energy than the closed state. A simple diffusion model indicates that the mean times for opening and closing of the B domain in the monomer with and without Mg2ATP are much smaller than the overall reaction time, which is on the order of seconds.
Retrieved from manubot
Cryopreservation of <i>Hydractinia symbiolongicarpus</i> sperm to support community-based repository development for preservation of genetic resources
Aidan L. Huene, Matthew L. Nicotra, Virginia M. Weis, Terrence R. Tiersch
Published: Nov 2020
  • The establishment of repositories for the Hydractinia research community will be essential for the future development, conservation, protection and distribution of genetic resources.
Анатолий Касян
Cannabidiol (CBD) Conversion to THC Possible Depending on Storage, but Not Likely in vivo
From Paper: Conversion of Cannabidiol (CBD) into Psychotropic Cannabinoids Including Tetrahydrocannabinol (THC): A Controversy in the Scientific Literature
Published: Jun 2020
  • We still need more research to begin to get a good understanding of how cannabinoids work
  • Controversy in literature regarding potential for conversion of CBD to THC may be due to sensitivity and nuances in detection methods
Adaptogenic and Anxiolytic Effects of Ashwagandha Root Extract in Healthy Adults: A Double-blind, Randomized, Placebo-controlled Clinical Study
Jaysing Salve, Sucheta Pate, Khokan Debnath, Deepak Langade
Published: Dec 2019
  • Ashwagandha root water extract helps reduce stress and anxiety.
Анатолий Касян
Steroidal lactones from Withania somnifera, an ancient plant for novel medicine
Mohammad Hossein Mirjalili, Elisabeth Moyano, Mercedes Bonfill, Rosa M. Cusido, Javier Palazón
Published: Jul 2009
  • Since vitanolides are likely to be derived from cholesterol, this is an appropriate starting point for discussing their biosynthesis. The first step in cholesterol biosynthesis is the activation of acetate by converting it to acetyl coenzyme A, abbreviated acetylCoA.
Анатолий Касян
Nutritive value and digestibility of macronutrients from sheep and alpaca skin hydrolysates as a new alternative in juvenile rainbow trout (Oncorhynchus mykiss) feeding
Araníbar-Araníbar, Marcelino Jorge, et al
Published: Nov 2020
  • The hydrolyzed sheep and alpaca skins had a high content of macronutrients with an acceptable apparent digestibility of nutrients, making them a viable alternative to improve the nutritive value of more economical feeds for rainbow trout feed.
Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection
Muema, Daniel M., et al
Published: Mar 2020
  • Although initiation of ART during Fiebig stages I - II AHI reversed the cytokine storm caused by HIV, these people in the acute phase still had significant eosinophil, basophil, and lymphocyte depletion and a temporary increase in monocytes before the onset of the disease. initiation of ART, which suggests that even ART, started during the onset of viremia, does not reverse all immune changes caused by HIV.
Анатолий Касян
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