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34
Date Added: Nov 25, 2021
Date Added: Nov 25, 2021
To advance a novel concept of debulking virus in the oral cavity, the primary site of viral replication, virus-trapping proteins CTB-ACE2 were express…
1
Date Added: Nov 3, 2021
Date Added: Nov 3, 2021
In order to successfully obtain a faculty position, postdoctoral fellows or ‘postdocs’, must submit an application which requires considerable time and effort to produce. These job applications are often reviewed by mentors and colleagues, but rarely are postdocs offered the opportunity to solicit feedback multiple times from reviewers with the same breadth of expertise often found on an academic search committee. To address this gap, this manuscript describes an international peer reviewing program for small groups of postdocs with a broad range of expertise to reciprocally and iteratively provide feedback to each other on their application materials. Over 145 postdocs have participated, often multiple times, over three years. A survey of participants in this program revealed that nearly all participants would recommend participation in such a program to other faculty applicants. Furthermore, this program was more likely to attract participants who struggled to find mentoring and support elsewhere, either because they changed fields or because of their identity as a woman or member of an underrepresented population in STEM. Participation in programs like this one could provide early career academics like postdocs with a diverse and supportive community of peer mentors during the difficult search for a faculty position. Such psychosocial support and encouragement has been shown to prevent attrition of individuals from these populations and programs like this one target the largest ‘leak’ in the pipeline, that of postdoc to faculty. Implementation of similar peer reviewing programs by universities or professional scientific societies could provide a valuable mechanism of support and increased chances of success for early-career academics in their search for independence.
3
Date Added: Nov 27, 2021
Date Added: Nov 27, 2021
Background Recently, the research on intelligent packaging is gaining momentum, primarily being driven by consumer preferences to food safety and reducing the resource waste. Freshness indicator is a kind of simple and efficient intelligent packaging technology, which can directly and scientifically indicate the freshness of food without complex operation. Freshness indicator shows great potential in the food supply chain. Scope and approach As an innovative food packaging method, freshness indicator can effectively monitor food freshness in real time without damaging food and packaging. The objective of this review is to provide relevant information on freshness indicators, such as release of food freshness indicators (carbon dioxide volatile salt-nitrogen sulfides, etc.), types (chemical chromogenic formulation, data carrier indicator, natural color formulation), safety assessment methods (toxicological assessment, exposure assessment), barriers and trends. Key findings and conclusions The potential of freshness indicators in the detection of perishable food freshness was emphasized. The applications of some freshness indicator products in food and the research demands of safety were also discussed.
7
Date Added: Nov 1, 2021
Date Added: Nov 1, 2021
Atmospheric cold plasma is a green and emerging technology, highly interesting to the food industry for its application. Dielectric Barrier Discharges (DBD) can generate atmospheric cold plasma inside sealed packages filled with air through the use of high voltages. This study investigated the use of a large gap DBD design to generate a plasma discharge within the headspace of packaged herring fillets, and its effects on microbiological and quality markers of the fish stored for 11 days at 4 °C. DBD plasma treatment conditions were 70 kV or 80 kV for 5 min treatment time. Results showed that the microbial load (total aerobic mesophilic, total aerobic psychrotrophics, Pseudomonas, lactic acid bacteria and Enterobacteriaceae) were significantly (p
4
Date Added: Nov 7, 2021
Date Added: Nov 7, 2021
The screening of biological hazards, chemical contaminants and allergens in food products is a major concern of food industry since they can cause ser…
36
Date Added: Aug 12, 2021
Date Added: Aug 12, 2021
Therapeutic proteins such as vaccines, antibodies, hormones, and cytokines are generally produced in bacteria or eukaryotic systems, including chicken eggs and mammalian or insect cell cultures, with high production yield according to well-defined regulatory guidelines ([ 1 ][1]). The use of plants for the production of therapeutic proteins, called molecular farming, was proposed as an alternative biomanufacturing method in 1986. The first and only plant-derived therapeutic protein for human use was approved in 2012 for the treatment of Gaucher disease. In 2019, a plant-produced influenza virus vaccine completed phase 3 clinical trials, with encouraging results ([ 2 ][2]). More recently, phase 3 trials for an adjuvanted plant-made vaccine (CoVLP) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (NCT04636697) began in March 2021. These successes have revived interest in plant-produced pharmaceuticals for human use, which could include edible drugs.
12
Date Added: Jul 26, 2021
Date Added: Jul 26, 2021
Stretchable wearable devices for the continuous monitoring of physiological signals from deep tissues are constrained by the depth of signal penetration and by difficulties in resolving signals from specific tissues. Here, we report the development and testing of a prototype skin-conformal ultrasonic phased array for the monitoring of haemodynamic signals from tissues up to 14 cm beneath the skin. The device allows for active focusing and steering of ultrasound beams over a range of incident angles so as to target regions of interest. In healthy volunteers, we show that the phased array can be used to monitor Doppler spectra from cardiac tissues, record central blood flow waveforms and estimate cerebral blood supply in real time. Stretchable and conformal skin-worn ultrasonic phased arrays may open up opportunities for wearable diagnostics.
3
Date Added: Nov 19, 2021
Date Added: Nov 19, 2021
Background Sodium chloride (NaCl) is an essential food additive used for preservation/flavor enhancement. Food processing with NaCl has higher sodium contents, raising the concern between the excess of dietary sodium as a risk factor for several health problems. Thus, there is a growing demand for alternatives to reduce sodium in processed foods. Scope and approach This systematic review comprehensively discusses how NaCl replacement can affect microbiological, sensory, and physicochemical attributes of processed fish products, besides identifying the current trend of a potential substitute. Key findings and conclusions KCl, K-lactate, CaCl2, MgCl2, SODA-LO salt microspheres were the main NaCl replacers found in smoked, restructured, fermented, read-to-eat, sushi, and fried cake fish products evaluating microbiological, physicochemical, and sensory parameters. The effectiveness of NaCl substitution is closely related to the particular characteristics of each fish product. Nevertheless, no study analyzed all quality parameters in each product, making it challenging to identify sodium substitution efficiency. KCl has higher research attention: the substitution of 25–50% of NaCl by KCl in combination with packaging conditions was enough to control microbial growth and reduce the prooxidant effect. However, the sensory quality was compromised, and adverse effects of high potassium intakes on health should be considered. Few studies analyzed the proximate composition, although seafood products have high protein and essential lipid content. Novel salt technologies as SODA-LO were identified as the current trend to lower sodium in fish products without taste impairment. Nevertheless, more studies are needed to elucidate the effects of its use on the overall quality of products.
3
Date Added: Nov 1, 2021
Date Added: Nov 1, 2021
Oral cancer is among the deadliest types of malignancy due to the late stage at which it is usually diagnosed, leaving the patient with an average five-year survival rate of less than 50%. The booming field of biosensing and point of care diagnostics can, in this regard, play a major role in the early detection of oral cancer. Saliva is gaining interest as an alternative biofluid for non-invasive diagnostics, and many salivary biomarkers of oral cancer have been proposed. While these findings are promising for the application of salivaomics tools in routine practice, studies on larger cohorts are still needed for clinical validation. This review aims to summarize the most recent development in the field of biosensing related to the detection of salivary biomarkers commonly associated with oral cancer. An introduction to oral cancer diagnosis, prognosis and treatment is given to define the clinical problem clearly, then saliva as an alternative biofluid is presented, along with its advantages, disadvantages, and collection procedures. Finally, a brief paragraph on the most promising salivary biomarkers introduces the sensing technologies commonly exploited to detect oral cancer markers in saliva. Hence this review provides a comprehensive overview of both the clinical and technological advantages and challenges associated with oral cancer detection through salivary biomarkers.
4
Date Added: Nov 4, 2021
Date Added: Nov 4, 2021
Substantial amounts of by-products are generated annually by the brewing industry, being currently undervalued. Nevertheless, the two major by-product…