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Trending Papers in oncology

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222
Published: Nov 2020
Published: Nov 2020
  • Evidence of B vitamin’s role in immune cell regulation has accumulated in recent years and may help to clarify the disparate findings of numerous studies attempting to link B vitamins to cancer development
  • This paper reviews the expanding literature examining the relationship between B vitamins and the immune system and diverse cancers
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Patrick Joyce
4
Published: Dec 2020
Published: Dec 2020
Recently, there has been great interest in developing Artificial Intelligence (AI) enabled computer-aided diagnostics solutions for the diagnosis of s…
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ALYSSA ENG
106
From Paper: The changing role of radiation oncology professionals in a world of AI – Just jobs lost – Or a solution to the under-provision of radiotherapy?
Published: Sep 2020
From Paper: The changing role of radiation oncology professionals in a world of AI – Just jobs lost – Or a solution to the under-provision of radiotherapy?
Published: Sep 2020
  • The main task of radiation oncology is planning and delivery of high precision radiotherapy to cancer patients. Since radiotherapy is relevant for more than 50% of all cancer patients, the role of radiotherapy in cancer management is substantial.
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ayotune adebayo
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ayotune adebayo
125
From Paper: The COVID-19 & Cancer Consortium (CCC19) and Opportunities for Radiation Oncology
Published: Dec 2020
From Paper: The COVID-19 & Cancer Consortium (CCC19) and Opportunities for Radiation Oncology
Published: Dec 2020
  • To date, there are more than 38,000,000 confirmed cases of coronavirus disease 2019 (COVID-19) worldwide, with over 1,000,000 deaths.
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ayotune adebayo
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ayotune adebayo
111
From Paper: Machine learning applications in radiation oncology: Current use and needs to support clinical implementation
Published: Nov 2020
From Paper: Machine learning applications in radiation oncology: Current use and needs to support clinical implementation
Published: Nov 2020
  • The use of artificial intelligence (AI)/ machine learning (ML) applications in radiation oncology is emerging, however no clear guidelines on commissioning of ML-based applications exist. The purpose of this study was therefore to investigate the current use and needs to support implementation of ML-based applications in routine clinical practice.
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ayotune adebayo
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ayotune adebayo
232
Published: Oct 2016
Published: Oct 2016
  • Application of this approach to other cancers with less standard treatments will introduce heterogeneity into clinical outcome and would need to be accounted for in the statistical analyses
  • In this manuscript the authors present a bioinformatics approach for connectivity mapping based on clinical outcomes collected on a large patient population followed by functional validation of the identified drugs
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Chen Wang
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2
Authors: Matthew B. Morgan, Jonathan L. Mates
Published: Jan 2021
Authors: Matthew B. Morgan, Jonathan L. Mates
Published: Jan 2021
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ALYSSA ENG
2
Authors: Wang, Chen, et al
Published: Jun 2014
Authors: Wang, Chen, et al
Published: Jun 2014
To reveal biologic mechanisms underlying clinical outcome of high-grade serous (HGS) epithelial ovarian carcinomas (EOC), we evaluated the association between tumor epigenetic changes and time to recurrence (TTR). We assessed methylation at approximately 450,000 genome-wide CpGs in tumors of 337 Mayo Clinic (Rochester, MN) patients. Semi-supervised clustering of discovery (n = 168) and validation (n = 169) sets was used to determine clinically relevant methylation classes. Clustering identified two methylation classes based on 60 informative CpGs, which differed in TTR in the validation set [R vs. L class, P = 2.9 × 10−3, HR = 0.52; 95% confidence interval (CI), 0.34–0.80]. Follow-up analyses considered genome-wide tumor mRNA expression (n = 104) and CD8 T-cell infiltration (n = 89) in patient subsets. Hypomethylation of CpGs located in 6p21.3 in the R class associated with cis upregulation of genes enriched in immune response processes (TAP1, PSMB8, PSMB9, HLA-DQB1, HLA-DQB2, HLA-DMA, and HLA-DOA), increased CD8 T-cell tumor infiltration (P = 7.6 × 10−5), and trans-regulation of genes in immune-related pathways (P = 1.6 × 10−32). This is the most comprehensive assessment of clinical outcomes with regard to epithelial ovarian carcinoma tumor methylation to date. Collectively, these results suggest that an epigenetically mediated immune response is a predictor of recurrence and, possibly, treatment response for HGS EOC. Cancer Res; 74(11); 3084–91. ©2014 AACR.
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Chen Wang
1
Authors: Charbonneau, Bridget, et al
Published: Apr 2014
Authors: Charbonneau, Bridget, et al
Published: Apr 2014
The presence of regulatory T cells (Treg) in solid tumors is known to play a role in patient survival in ovarian cancer and other malignancies. We assessed inherited genetic variations via 749 tag single-nucleotide polymorphisms (SNP) in 25 Treg-associated genes (CD28, CTLA4, FOXP3, IDO1, IL10, IL10RA, IL15, 1L17RA, IL23A, IL23R, IL2RA, IL6, IL6R, IL8, LGALS1, LGALS9, MAP3K8, STAT5A, STAT5B, TGFB1, TGFB2, TGFB3, TGFBR1, TGRBR2, and TGFBR3) in relation to ovarian cancer survival. We analyzed genotype and overall survival in 10,084 women with invasive epithelial ovarian cancer, including 5,248 high-grade serous, 1,452 endometrioid, 795 clear cell, and 661 mucinous carcinoma cases of European descent across 28 studies from the Ovarian Cancer Association Consortium (OCAC). The strongest associations were found for endometrioid carcinoma and IL2RA SNPs rs11256497 [HR, 1.42; 95% confidence interval (CI), 1.22–1.64; P = 5.7 × 10−6], rs791587 (HR, 1.36; 95% CI, 1.17–1.57; P = 6.2 × 10−5), rs2476491 (HR, = 1.40; 95% CI, 1.19–1.64; P = 5.6 × 10−5), and rs10795763 (HR, 1.35; 95% CI, 1.17–1.57; P = 7.9 × 10−5), and for clear cell carcinoma and CTLA4 SNP rs231775 (HR, 0.67; 95% CI, 0.54–0.82; P = 9.3 × 10−5) after adjustment for age, study site, population stratification, stage, grade, and oral contraceptive use. The rs231775 allele associated with improved survival in our study also results in an amino acid change in CTLA4 and previously has been reported to be associated with autoimmune conditions. Thus, we found evidence that SNPs in genes related to Tregs seem to play a role in ovarian cancer survival, particularly in patients with clear cell and endometrioid epithelial ovarian cancer. Cancer Immunol Res; 2(4); 332–40. ©2014 AACR.
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Chen Wang
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