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2
Published: Aug 1, 2021
Published: Aug 1, 2021
The cGAS-STING pathway plays essential roles in detecting cytosolic dsDNA and initiating antiviral and antibacterial responses in vertebrates. However, knowledge about its function in antiviral response of invertebrates is very limited. In the present study, a gene encoding a Mab21-containing protein, a cGAS homologue, was identified from a decapod crustacean Litopenaeus vannamei and designated as LvMab21cp. LvMab21cp was mainly distributed in intestine and hepatopancreas, showing similar expression profile with other genes in the cGAS-STING pathway, such as LvSTING and LvIRF. The expression levels of LvMab21cp, LvSTING and LvIRF were up-regulated in intestine and hepatopancreas of shrimp after white spot syndrome virus (WSSV) infection. Knockdown of LvMab21cp by dsRNA-mediated RNA interference could decrease the expression levels of its putative downstream genes, including LvSTING, LvIRF, LvVago4 and LvVago5, and enhance the in vivo propagation of WSSV in shrimp. Overexpression of LvMab21cp and LvSTING in HEK 293T cells activated the expression of mammalian IFNs upon simulation with interferon stimulatory DNA (ISD). These data suggest that LvMab21cp was a cGAS homologue, a member of the shrimp cGAS-STING pathway, and play an important role during WSSV infection. To our knowledge, this is the first report to show the role of the cGAS-STING pathway in the antiviral response of invertebrates, which will provide new insights into the innate immunity of invertebrates.
1
Published: Oct 1, 2021
Authors: Christian W Thorball, Jacques Fellay, Alessandro Borghesi
Published: Oct 1, 2021
Authors: Christian W Thorball, Jacques Fellay, Alessandro Borghesi
1
Published: Oct 1, 2021
Authors: Marie Tauber, Fang Wang, Brian Kim, Nicolas Gaudenzio
Published: Oct 1, 2021
Authors: Marie Tauber, Fang Wang, Brian Kim, Nicolas Gaudenzio
1
Published: Jul 1, 2021
Authors: M. Fathimath Muneesa, Sadiya B. Shaikh, T.M. Jeena, Yashodhar P. Bhandary
Published: Jul 1, 2021
Authors: M. Fathimath Muneesa, Sadiya B. Shaikh, T.M. Jeena, Yashodhar P. Bhandary
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