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Trending Papers in pharmacology

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Today
2
A review of mRNA vaccines and their applications
From Paper: mRNA vaccines — a new era in vaccinology
Authors:
Norbert Pardi, Michael J. Hogan, Frederick W. Porter, Drew Weissman
Published: Apr 2018
  • mRNA cancer vaccines have shown some promising results in clinical trials displaying antigen-specific T cell responses and prolonged disease-free survival in some cases
  • mRNA vaccines have elicited potent immunity against infectious disease targets in animal models of influenza virus, Zika virus, rabies virus and others, especially in recent years, using lipid-encapsulated or naked forms of sequence-optimized mRNA
13
Cannabidiol (CBD) Conversion to THC Possible Depending on Storage, but Not Likely in vivo
From Paper: Conversion of Cannabidiol (CBD) into Psychotropic Cannabinoids Including Tetrahydrocannabinol (THC): A Controversy in the Scientific Literature
Published: Jun 2020
  • We still need more research to begin to get a good understanding of how cannabinoids work
  • Controversy in literature regarding potential for conversion of CBD to THC may be due to sensitivity and nuances in detection methods
33
Immunity to SARS-CoV-2 lasts for at least 6 months and potentially up to multiple years
From Paper: Immunological memory to SARS-CoV-2 assessed for greater than six months after infection
Published: Nov 2020
  • SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months
  • In terms of the length of immunity observed - spike IgG was relatively stable over 6+ months and spike-specific memory B cells were more abundant at 6 months than at 1 month
21
Nutraceutical or Pharmacological Potential of Moringa
From Paper: Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.
Published: Mar 2018
  • Many studies have revealed its therapeutic value including anti-diabetes, anti-rheumatoid arthritis, anti-atherosclerosis, anti-infertility, pain relief, anti-depression, and diuretic and thyroid regulation
  • Moringa is reported to enhance a broad range of biological functions including anti-inflammatory, anti-cancer, hepatoprotective, and neuroprotective functions
5
Stress-relieving and pharmacological actions of Ashwagandha
From Paper: An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study
Published: Sep 2019
  • The findings indicated that compared with placebo, ashwagandha intake was associated with a reduction in fasting, morning cortisol (stress hormone) and DHEA-S (steroidal hormones)
  • In this randomized, double-blind, placebo-controlled trial, the 60-day intake of an ashwagandha extract (Shoden) in mildly anxious, healthy adults resulted in significant emotional improvements over time. Based on the HAM-A, anxiety levels reduced in participants taking ashwagandha,. Mood-enhancing effects of ashwagandha was provided by positive overall improvements in the DASS-21, a measure of depressive, anxiety, and stress symptoms.
50
Unusual electron spin polarization tied to loss of consciousness via general anaesthesia in fruit flies (Drosophila)
From Paper: Figure 10 rev 2
Published: Aug 2014
  • General anesthesia, whose mechanism of action to eliminate consciousness is still not fully understood, is tied to electron spin signal in fruit flies
  • More broad connection between electron spin currents in cells and consciousness of nervous system is implied
26
Network analysis predicts melatonin as a potential drug for the prevention and treatment of COVID-19
From Paper: A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
Published: Nov 2020
  • Melatonin was significantly associated with a 52% reduced likelihood of a positive laboratory test result for SARS-CoV-2 in black Americans
  • The authors created a pan-coronavirus protein-protein interaction (PPI) network by combining HCoV-PPI and SARS2-PPI. This data was used to identify broad-spectrum antiviral medications for SARS-CoV-2
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34
The mechanism behind how cannabidiol (CBD) treats Pulmonary Arterial Hypertension has been established
From Paper: Cannabidiol Attenuates Pulmonary Arterial Hypertension by Normalizing the Mitochondrial Function in Vascular Smooth Muscle Cells
Published: Nov 2020
  • The results showed that CBD alleviated PAH by recovering mitochondrial energy metabolism, normalizing the hypoxia-induced oxidant stress, inhibiting abnormal glycolysis and lactate accumulation in cannabinoids receptors-independent manner
  • This study explored the functions of CBD in both PASMCs proliferation test in vitro, and preventive and therapeutic PAH rodent models in vivo
3
The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No "Strain,'' No Gain
From Paper: The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No ``Strain,'' No Gain
Published: Jan 2019
  • Hhggffg
  • Synergy of molecules in natural cannabis yields applications unmatched by artificial isolation or synthesis of individual cannabinoids
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