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Trending Papers in pharmacology

A review of mRNA vaccines and their applications
From Paper: mRNA vaccines — a new era in vaccinology
Norbert Pardi, Michael J. Hogan, Frederick W. Porter, Drew Weissman
Published: Apr 2018
  • mRNA cancer vaccines have shown some promising results in clinical trials displaying antigen-specific T cell responses and prolonged disease-free survival in some cases
  • mRNA vaccines have elicited potent immunity against infectious disease targets in animal models of influenza virus, Zika virus, rabies virus and others, especially in recent years, using lipid-encapsulated or naked forms of sequence-optimized mRNA
Cannabidiol (CBD) Conversion to THC Possible Depending on Storage, but Not Likely in vivo
From Paper: Conversion of Cannabidiol (CBD) into Psychotropic Cannabinoids Including Tetrahydrocannabinol (THC): A Controversy in the Scientific Literature
Published: Jun 2020
  • We still need more research to begin to get a good understanding of how cannabinoids work
  • Controversy in literature regarding potential for conversion of CBD to THC may be due to sensitivity and nuances in detection methods
Immunity to SARS-CoV-2 lasts for at least 6 months and potentially up to multiple years
From Paper: Immunological memory to SARS-CoV-2 assessed for greater than six months after infection
Published: Nov 2020
  • SARS-CoV-2-specific CD4+ T cells and CD8+ T cells declined with a half-life of 3-5 months
  • In terms of the length of immunity observed - spike IgG was relatively stable over 6+ months and spike-specific memory B cells were more abundant at 6 months than at 1 month
Nutraceutical or Pharmacological Potential of Moringa
From Paper: Nutraceutical or Pharmacological Potential of Moringa oleifera Lam.
Published: Mar 2018
  • Many studies have revealed its therapeutic value including anti-diabetes, anti-rheumatoid arthritis, anti-atherosclerosis, anti-infertility, pain relief, anti-depression, and diuretic and thyroid regulation
  • Moringa is reported to enhance a broad range of biological functions including anti-inflammatory, anti-cancer, hepatoprotective, and neuroprotective functions
Stress-relieving and pharmacological actions of Ashwagandha
From Paper: An investigation into the stress-relieving and pharmacological actions of an ashwagandha (Withania somnifera) extract: A randomized, double-blind, placebo-controlled study
Published: Sep 2019
  • The findings indicated that compared with placebo, ashwagandha intake was associated with a reduction in fasting, morning cortisol (stress hormone) and DHEA-S (steroidal hormones)
  • In this randomized, double-blind, placebo-controlled trial, the 60-day intake of an ashwagandha extract (Shoden) in mildly anxious, healthy adults resulted in significant emotional improvements over time. Based on the HAM-A, anxiety levels reduced in participants taking ashwagandha,. Mood-enhancing effects of ashwagandha was provided by positive overall improvements in the DASS-21, a measure of depressive, anxiety, and stress symptoms.
Unusual electron spin polarization tied to loss of consciousness via general anaesthesia in fruit flies (Drosophila)
From Paper: Figure 10 rev 2
Published: Aug 2014
  • General anesthesia, whose mechanism of action to eliminate consciousness is still not fully understood, is tied to electron spin signal in fruit flies
  • More broad connection between electron spin currents in cells and consciousness of nervous system is implied
Network analysis predicts melatonin as a potential drug for the prevention and treatment of COVID-19
From Paper: A network medicine approach to investigation and population-based validation of disease manifestations and drug repurposing for COVID-19
Published: Nov 2020
  • Melatonin was significantly associated with a 52% reduced likelihood of a positive laboratory test result for SARS-CoV-2 in black Americans
  • The authors created a pan-coronavirus protein-protein interaction (PPI) network by combining HCoV-PPI and SARS2-PPI. This data was used to identify broad-spectrum antiviral medications for SARS-CoV-2
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The mechanism behind how cannabidiol (CBD) treats Pulmonary Arterial Hypertension has been established
From Paper: Cannabidiol Attenuates Pulmonary Arterial Hypertension by Normalizing the Mitochondrial Function in Vascular Smooth Muscle Cells
Published: Nov 2020
  • The results showed that CBD alleviated PAH by recovering mitochondrial energy metabolism, normalizing the hypoxia-induced oxidant stress, inhibiting abnormal glycolysis and lactate accumulation in cannabinoids receptors-independent manner
  • This study explored the functions of CBD in both PASMCs proliferation test in vitro, and preventive and therapeutic PAH rodent models in vivo
The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No "Strain,'' No Gain
From Paper: The Case for the Entourage Effect and Conventional Breeding of Clinical Cannabis: No ``Strain,'' No Gain
Published: Jan 2019
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  • Synergy of molecules in natural cannabis yields applications unmatched by artificial isolation or synthesis of individual cannabinoids
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