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Trending Papers in pharmacology

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Today
12
The solidarity trial - exploring repurposed antiviral drugs for efficacy in treating COVID-19
From Paper: Repurposed antiviral drugs for COVID-19; interim WHO SOLIDARITY trial results
Published: Oct 2020
  • The main outcomes of mortality, initiation of ventilation and hospitalization duration were not clearly reduced by any study drug
  • Hydroxychloroquine and Lopinavir were discontinued for futility on June 18 and July 4, 2020, respectively; Interferon is ceasing on October 16
Submitted by Patrick Joyce
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7
Serotonergic psychedelics show promise as a potential treatment for autoimmune diseases
From Paper: Psychedelics as a novel approach to treating autoimmune conditions
Published: Oct 2020
  • This literature review explores existing evidence that psychedelic compounds may offer a potential novel application in the treatment of pathologies related to autoimmunity
  • The authors propose that psychedelics hold the potential to attenuate or even resolve autoimmunity by targeting psychosomatic origins, maladaptive chronic stress responses, inflammatory pathways, immune modulation and enteric microbiome populations
Submitted by Garrett Young
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9
Metformin decreases signs of aging in fat cells
From Paper: Metformin alleviates aging-associated cellular senescence of human adipose stem cells and derived adipocytes
Authors:
Mantecon, Matthieu, et al
Published: Oct 2020
  • When aged-donor ASCs were treated with metformin, senescence, oxidative stress and mitochondrial dysfunction returned to the levels observed in young-donor ASCs
  • Oxidative stress and mitochondrial dysfunction occurred earlier in adipocytes derived from aged-donor than from young-donor ASCs, leading to insulin resistance and impaired adipogenesis
Submitted by Age Old
Slide 1 of 1
22
The hallucinogen DMT regulates neurogenesis both in vitro and in vivo
From Paper: N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
Authors:
Morales-Garcia, Jose A., et al
Published: Sep 2020
  • The results show both in vitro and in vivo that DMT is a key regulator in the activity of adult neural stem cells (NSC) located in the subgranular zone (SGZ), one of the main adult neurogenic niches
  • This study uses an in vitro model of adult neurogenesis to show that DMT promotes the proliferation and migration of progenitor cells and induces their differentiation mainly into a neuronal phenotype
Submitted by Patrick Joyce
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4
Low to moderate alcohol drinking is associated with better cognition in older age than complete abstinence from alcohol
From Paper: Association of Low to Moderate Alcohol Drinking With Cognitive Functions From Middle to Older Age Among US Adults
Published: Jun 2020
  • Weekly alcohol consumption had U-shaped relationships with the cognitive functions assessed, with the strongest associations with better cognitive functions at a dosage of 10 to 14 drinks per week for all participants
  • Low to moderate drinking was associated with consistently high cognitive function trajectories. Cognitive test scores at the baseline middle-aged assessment were relatively high and remained high at each subsequent assessment. In addition, there was a decreased rate of cognitive decline with age for middle-aged or older US adults for low to moderate drinkers
Submitted by Patrick Joyce
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8
How sex and gender influence the physiological effect of psychoactive drugs
From Paper: Sex and Gender Differences in the Effects of Novel Psychoactive Substances
Published: Sep 2020
  • This work collects the little knowledge reached so far on the effects of NPS in male and female animal and human subjects, highlighting how much sex and gender differences in the effects of NPS has yet to be studied and understood
  • Men are more likely than women to use almost all types of illicit drugs and to present to emergency departments for serious or fatal intoxications
Submitted by Patrick Joyce
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8
A single dose of acetaminophen (Tylenol) will make a person more likely to take risks
From Paper: Effects of acetaminophen on risk taking
  • The results indicate that acetaminophen can increase risk-taking, which may be due to reductions in risk perceptions
  • This study tested the hypothesis that acute acetaminophen consumption (1000 mg) could influence important judgments and decisions concerning risk
Submitted by Will McBurnie
Slide 1 of 1
2
An Alpaca antibody can be used to neutralize SARS-CoV-2 and prevent its entry into target host cells
From Paper: An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
Published: Sep 2020
  • In addition to neutralization activity, we show that Ty1 can be used as a detection reagent in flow cytometry and immunofluorescence demonstrating its suitability as a research tool and for diagnostics
  • Ty1 was identified by binding assay after two consecutive rounds of phage display, simultaneously monitoring sequence enrichment by next generation sequencing
Submitted by Patrick Joyce
10
Telomerase gene therapy prevents age-related fibrotic lung disease
From Paper: Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging
Published: Oct 2020
  • The results demonstrate telomere shortening with age in the lungs of wild-type mice, reaching at old ages values similar to those of young G3 Tert−/− mice
  • Mice with a mutation in TERT (telomerase gene) and a control, mice without a TERT mutation, were both given telomerase gene therapy and then assessed for telomere shortening and lung fibrosis at various time points throughout their lives
Submitted by Patrick Joyce
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9
Microdosing LSD decreases the perception of pain in healthy volunteers to a similar extent as opioids prescribed for moderate to severe pain
From Paper: A low dose of lysergic acid diethylamide decreases pain perception in healthy volunteers
Published: Aug 2020
  • Changes in pain tolerance and subjective pain perception induced by LSD 20 µg were of medium to large effect size and comparable in magnitude to those observed with the CPT after administration of opioids, such as oxycodone 20 mg and morphine 10–20 mg to healthy volunteers
  • Separate LSD–placebo contrasts revealed that LSD 20 µg increased pain tolerance (p=0.006) and decreased painfulness (p=0.012) and unpleasantness (p=0.008)
Submitted by Patrick Joyce
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